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Co trimoxazole mechanism of action

MECHANISM OF ACTION sulfamethoxazole -> inhibits bacterial synthesis of dihydrofolic acid trimethoprim -> blocks production of tetrahydrofolic acid -> blocks two consecutive steps in the biosythesis of nucleic acids and proteins essential to bacteria Co-trimoxazole is a combination of Sulfamethoxazole and Trimethoprim in the ratio of 5:1 (5 parts of Sulfamethoxazole and 1 part of Trimethoprim). These two agents inhibit two consecutive steps in the biosynthesis of nucleic acid in the microorganisms. When used individually they are bacteristatic (they reduce the growth of the microorganisms) Warfarin: co-trimoxazole has been shown to potentiate the anticoagulant activity of warfarin via stereo-selective inhibition of its metabolism. Sulfamethoxazole may displace warfarin from plasma-albumin protein-binding sites in vitro. Careful control of the anticoagulant therapy during treatment with Co-Trimoxazole is advisable Pharmacodynamics Antibacterial action: Co-trimoxazole is generally bactericidal; it acts by sequential blockade of folic acid enzymes in the synthesis pathway. The sulfamethoxazole component inhibits formation of dihydrofolic acid from para-aminobenzoic (PABA), whereas trimethoprim inhibits dihydrofolate reductase

Co-trimoxazole • LITFL • CCC Pharmacolog

Co-trimoxazole Mutalik Pharmacolog

  1. Trimethoprim-sulfamethoxazole (TMP-SMX), also known as co-trimoxazole, is a combination of two antimicrobial agents that act synergistically against a wide variety of bacteria. Although other combinations of sulfonamides are available with trimethoprim, TMP-SMX is by far the most widely used
  2. Mechanism of Action of Co-trimoxazole Co-trimoxazole is bactericidal due to the double inhibition of bacterial folic acid synthesis. Antibiotic Spectrum of Co-trimoxazole: Bacteria causing urinary tract infection such as E. coli, Enterococci, Mycoplasma, Klebsiella, Serratia, Enterobacter (KES group), but with increasing resistance rates
  3. protein-binding sites in vitro. Careful control of the anticoagulant therapy during treatment with co-trimoxazole is advisable

Co-Trimoxazole Tablets 80/400mg - Summary of Product

  1. Medical uses. Co-trimoxazole was claimed to be more effective than either of its components individually in treating bacterial infections, although this was later disputed. Because it has a higher incidence of adverse effects, including allergic responses, its use has been restricted in many countries to very specific circumstances where its improved efficacy has been demonstrated
  2. Co-trimoxazole has been used in the treatment of gonorrhea caused by penicillinase-producing Neisseria gonorrhoeae. Although other anti-infective agents are generally recommended by the US Centers for Disease Control and many clinicians for the treatment of urogenital or anorectal infections caused by penicillinase-producing Neisseria gonorrhoeae, co-trimoxazole may be effective for the.
  3. In this video , I have discussed about the Rationale for using Sulphamethoxazole with Trimethoprim as combination .The mechanism of action of Cotrimoxazole h..
  4. The combination of trimethoprim with sulfamethoxazole (as co-trimoxazole) acts synergistically to prevent folate synthesis by bacteria. However, resistance to the sulfamethoxazole component and the incidence of unwanted effects limit the value of this combination
  5. Mechanism of action Trimethoprim is a reversible inhibitor of dihydrofolate reductase, one of the principal enzymes catalyzing the formation of tetrahydrofolic acid (THF) from dihydrofolic acid (DHF). 14 Tetrahydrofolic acid is necessary for the biosynthesis of bacterial nucleic acids and proteins and ultimately for continued bacterial survival.

co-trimoxazole (trimethoprim-sulfamethoxazole

Co-trimoxazole Mechanism of Action. Co-trimoxazole, generally bactericidal, a combination of trimethoprim and sulfamethoxazole. It acts by sequential blockade of folic acid enzymes in the synthesis pathway. The sulfamethoxazole component inhibits the formation of dihydrofolic acid from para-aminobenzoic (PABA), whereas trimethoprim inhibits. An 86-year-old Caucasian male developed hyponatremia while on trimethoprim-sulfamethoxazole (TMP-SMX) 80/400 mg, one tablet by mouth twice daily. Upon discontinuation of therapy, his serum sodium and symptoms improved. He was inadvertently rechallenged several months later with TMP-SMX and had simil Varney reported in this small pilot study that co-trimoxazole improved exercise capacity, breathlessness and symptom scores in the actively treated group. 2 Although the mechanism whereby co-trimoxazole achieved this was not clear from this study it may have related to altered expression of vascular endothelial growth factor which has been subsequently related to both disease severity, progression and outcome in IPF. Pharmacology Sulfamethoxazole interferes with bacterial folic acid synthesis and growth via inhibition of dihydrofolic acid formation from para-aminobenzoic acid; trimethoprim inhibits dihydrofolic acid reduction to tetrahydrofolate resulting in sequential inhibition of enzymes of the folic acid pathwa

Co-trimoxazole Side Effects. Generic name: sulfamethoxazole / trimethoprim Medically reviewed by Drugs.com. Last updated on Sep 15, 2020. Consumer; Professional; FAQ; Note: This document contains side effect information about sulfamethoxazole / trimethoprim. Some of the dosage forms listed on this page may not apply to the brand name Co-trimoxazole.. For the Consume Actions. Fixed combination of sulfamethoxazole (SMZ), an intermediate acting antiinfective sulfonamide, and trimethoprim (TMP), a synthetic antiinfective. Both components of the combination are synthetic folate antagonist antiinfectives. Mechanism of action is principally enzyme inhibition, which prevents bacterial synthesis of essential. SAQ/Viva. Explain mechanism of action of Insulin. Insulin receptor is an enzyme linked receptor having two subunits - alpha and beta. The beta subunit is associated with the enzyme tyrosine kinase.It phosphorylates the tyrosine residues, which leads to activation of PIP3 Kinase Mechanism of Action of Co-trimoxazole N/A Pharmacokinets of Co-trimoxazole N/A Onset of Action for Co-trimoxazole N/A Duration of Action for Co-trimoxazole N/A Half Life of Co-trimoxazole N/A Side Effects of Co-trimoxazole N/A Contra-indications of Co-trimoxazole N/A Special Precautions while taking Co-trimoxazole N/ The mechanism of action is still unknown. Type and duration of application. The usual dose for adults is 2 × 960 mg per day (800 mg each of sulfamethoxazole and 160 mg of trimethoprim). In Pneumocystis carinii pneumonia, the dose is up to 5 times the standard dose. For long-term use, 480 mg of co-trimoxazole are usually used twice a day

Naber K, Vergin H, and Weigand W, Pharmacokinetics of Co-trimoxazole and Co-tetroxazine in Geriatric Patients, Infection, 1981, 9(5):239-43. Noto H, Kaneko Y, Takano T, et al, Severe Hyponatremia and Hyperkalemia Induced by Trimethoprim-Sulfamethoxazole in Patients With Pneumocystis carinii Pneumonia, Intern Med, 1995, 34(2):96-9 Co-trimoxazole is a combination of two antibacterial medicines - a sulfonamide medicine called sulfamethoxazole, and trimethoprim.Although it has been prescribed widely for a range of infections in the past, it has very occasionally been associated with some serious side-effects CO-TRIMOXAZOLE DRUG PROFILE BASIC FEATURES: Class: Antimetabolite, sulfonamide antibiotics. Mechanism of action: 1. Cotrimoxazole consists of (sulfamethoxazole+ trimethoprim). 2. Sulfamethoxazole competes with PABA (para-amino benzoic acid) inhibits bacterial synthesis of dihydrofolic acid. 3

Co-trimoxazole: MedlinePlus Drug Informatio

Co-trimoxazole presently remains the first choice for prophylaxis and treatment of Pneumocystis carinii infections. The high incidence of adverse Its mechanism of action is unclear but it may result from binding to DNA (28-30). Its anti- pneumocystis activity was recognized in 1957, when it. Mechanism of Action. Sulfamethoxazole inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA). Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the required enzyme, dihydrofolate reductase Mechanism of Action. Sulfamethoxazole interferes with bacterial folic acid synthesis and growth via inhibition of dihydrofolic acid formation from para-aminobenzoic acid; trimethoprim inhibits dihydrofolic acid reduction to tetrahydrofolate resulting in sequential inhibition of enzymes of the folic acid pathway

Mechanism of Action. Blocks 2 consecutive steps in the biosynthesis of nucleic acids and proteins essential to many bacteria. Trimethoprim: Inhibits dihydrofolate reductase, thereby blocking production of tetrahydrofolic acid from dihydrofolic acid The mechanism of hyperkalaemia when co-trimoxazole is given with spironolactone. (Septrin) and spironolactone are taken together. However, the association. prophylaxis for pneumocystis carinii infection1. It is worthwhile. decreasing glomerular filtration rate (GFR). also triamterene)2,3

Cotrimoxazole (Trimethoprim/sulfamethoxazole

Mechanism of Action Sulfamethoxazole is a sulfonamide (antimicrobial drug class) that works directly on the synthesis of folate inside microbial organisms, e.g., bacteria. Sulfamethoxazole achieves this directly as a competitor of p-aminobenzoic acid (PABA) during the synthesis of dihydrofolate via inhibition of the enzyme dihydropteroate synthase 12. Composition • Cotrimoxazole is an combination of trimethoprim and sulphamethoxazole in the ratio of 1:5 • The reason for selecting these drugs is they have an equal t1/2 of approximately 10 hours • Their mechanism of action help in sequential blockade in the pathway of an obligate enzymatic reaction in bacteria. 13 Synopsis: Trimethoprim,1 which has been widely available for several years in combination with sulphamethoxazole as co-trimoxazole, 2 is now available for use alone in the treatment of acute uncomplicated urinary tract infections. Trimethoprim, which is active against a wide range of Gram-positive and Gram-negative aerobic bacteria, is readily absorbed by the oral route and is widely.

Co-trimoxazole(Trimethoprim-sulfamethoxazole) SpringerLin

Co-trimoxazole in rheumatoid arthritis: a comparison with sulphapyridine. Astbury C(1), Hill J, Bird HA. Author information: (1)Clinical Pharmacology Unit, Royal Bath Hospital, Harrogate. The antirheumatoid activity of sulphasalazine and sulphapyridine may result from their antibacterial properties Valsartan, sold under the trade name Diovan among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. It is a reasonable initial treatment for high blood pressure. It is taken by mouth. Versions are available as the combination valsartan/hydrochlorothiazide, valsartan/amlodipine, valsartan. Co Trimoxazole tablet suppliers and exporters can order different strengths of the medicine in India containing the active ingredients in the proportionate quantities. Mechanism of Action and Pharmacology. Wellonapharma's Co trimoxazole Tablet improves the patient's condition by performing the following functions: Stopping bacterial growth Safety and Efficacy of Co-Trimoxazole for Treatment and Prevention of Plasmodium falciparum Malaria: A Systematic Review. By Umberto D'Alessandro. Safety of Cotrimoxazole in Pregnancy. By Zara Shubber. Safety of cotrimoxazole in pregnancy: a systematic review and meta-analysis

Mechanism of action: Co-Trimoxazole: It is a combination of a sulfonamide (sulfamethoxazole) and trimethoprim in the proportion of 5 parts to 1 part and is bactericidal because of their synergistic activity. It has excellent tissue penetration, including bone, prostate and brain. Co-trimoxazole is the drug of choice in Pneumocystis crainii. Cotrimoxazole is a medicine, an antibiotic. It is used to treat or prevent certain types of infections caused by bacteria. Cotrimoxazole is made up of 2 medicines, sulfamethoxazole and trimethoprim. You may hear cotrimoxazole called by its brand n.. Common Side Effects. GI upset, including antibiotic-associated C. difficile infection. A degree of allergy to penicillin is very common, affecting up to 10% of the population. Cephalosporins and Carbapenems. These antibiotics are grouped together due to their similar structural properties and mechanisms of action. Mechanism

Pharmacology of Cotrimoxazole - IndiaStudyChannel

Co-trimoxazole is contraindicated in people with a previous hypersensitivity reaction or severe hepatic damage. Severe renal impairment, bone marrow depression and agranulocytosis are also contraindications to use of co-trimoxazole, unless these can be closely monitored for and the clinical need outweighs the risk Co-trimoxazole had an HR of 1.48 (95% CI, 0.78-2.81) and doxycycline, HR of composite of clinical outcomes that was thought to be clinically relevant 14 and more reflective of the anticipated mechanism of action of antimicrobial therapy 25 in contrast to the more traditional longitudinal change in FVC. 26 As expected this study's patient. Mechanism of action. Oxytetracycline inhibits cell growth by inhibiting translation. This attaches to the ribosomal subunit 30S and prevents the amino-acyl tRNA binding to a position of ribosome A. The binding is reversible in nature. Oxytetracycline is lipophilic, and can move via the cell membrane rapidly or slowly through porin channels in. Antimicrobial mechanism of action. April 14, 2021 April 20, The mechanisms of host protection are primarily responsible for the infection's eradication. Minimal inhibitory concentration Co-Trimoxazole (Combination Of Trimethoprim And Sulfamethoxazole In A 1:5 Ratio

Medical Pharmacology: Antiviral DrugsSulfonamides and trimethoprim

UpToDat

A range of authoritative and up-to-date textbooks on key clinical issues related to pregnancy and childbirth. Masterclass Lectures. Lectures and slide presentations on key topics - providing in-depth understanding. The Welfare of Women. View details of GLOWM's extensive new programme for doctors, nurses/midwives and women. Global Health. Dosage/Direction for Use. 1 tab once daily for at least 4 wk. Patient stabilized w/ bisoprolol 2.5 mg & perindopril 2.5 mg ½ tab of 5 mg/5 mg once daily. Patient stabilized w/ bisoprolol 2.5 mg & perindopril 5 mg ½ tab of 5 mg/10 mg once daily. Click to view Cosyrel detailed prescribing information Mechanism of action Trimethoprim acts by interfering with the action of bacterial dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid.Tetrahydrofolic acid is an essential precursor in the de novo synthesis of the DNA nucleotide thymidine.Bacteria are unable to take up folic acid from the environment (i.e. the infection host) and are thus dependent on their own de novo synthesis fluoroquinolones mechanism of action. inhibit enzymes required for DNA replication and cell division (DNA gyrase and topoisomerase IV) When gram negative organisms are the target, flouroquinolones bind to _____ DNA gyrase Patient w/ renal impairment CrCl ≥60 5 mg/day. 30-60 CrCl 2.5 mg/day. 15-30 CrCl 2.5 mg every other day. <15 mg CrCl 2.5 mg on the day of dialysis. The dose should be taken after dialysis in hemodialysis patients. 5 mg: Symptomatic heart failure Starting dose: 2.5 mg/day. May be increased to 5 mg once daily after 2 wk if tolerated

Co-trimoxazol

Generic Name: Co-trimoxazole Prophylaxis Possible Brand Name: Septrin Classification: A combination of trimethoprim and sulfamethoxazole and is in a class of medications called sulfonamides. It works by stopping the growth of bacteria Frequency: 4 weeks Dosage: Not mentioned Route : Ora Mechanism of Action of Trimethoprim (An Anti-Malarial Drug): Trimethoprim is chemically related to the antimalarial drug pyrimethamine. Both the drugs, trimethoprim and pyrimethamine are folate antagonists. Trimethoprim resembles the pteridine moiety of the folate and it resembles the bacterial dihydrofolate reductase. This enzyme is more sensitive to trimethoprim than the enzyme present in. Certain factors such as advanced age, comorbidities, and medications (e.g., co-trimoxazole, aminoglycosides, or cimetidine) taken on a regular basis already lead to a reduction in glomerular filtration rate (GFR), increasing the risk of nephrotoxicity associated with NSAIDs use, contributing to the development of side effects As the pathogenesis of IPF is unknown the potential mechanisms of action of co-trimoxazole are uncertain. Co-trimoxazole is a broad-spectrum antibiotic with bactericidal effects against respiratory pathogens and the role of infection in IPF is becoming more evident . However, it may have non-antimicrobial effects, targeting cellular processes. Sulfamethoxazole & Trimethoprim. Trade Names: Sulfamethoxazole with trimethoprim ( Cotrimoxazole or Bactrim ® ) (Septra ®) Mechanism of Action: Sulfonamides competitively inhibit the incorporation of para-aminobenzoic acid (PABA) into dihydropteroic acid, a precursor of folic acid. Trimethoprim is an inhibitor of dihydrofolate reductase and.

the mechanism of action of trimethoprim, to manage trimethoprim-induced hyperkalaemia. 3. Discussion Co-trimoxazole is a combination antibiotic made up of trimethoprim and sulphamethoxazole that is first line treatment for both mild and severe PJP [1]. Despite its documentation in the literature since 1983 [2], the com Mechanism of Action. Co-trimoxazole, for example, is a combination of sulfamethoxazole and trimethoprim.Sulfonamides such as sulfamethoxazole tie up the first enzyme in the pathway, the conversion of para-aminobenzoic acid to dihydropteroic acid. Trimethoprim binds to the third enzyme in the pathway, an enzyme that is responsible for. Stop motion animation of co-trimoxazole mechanism of action This un-narrated clay animation highlights the inhibitory effects of co-trimoxazole on DHPS and DHFR, thus preventing the conversion of PABA to dihydrofolic acid and tetrahydrofolic acid

Co-Trimoxazole 80/400mg Tablets - Summary of Product

The biochemical basis of the activity of trimethoprim (TMP) is reviewed. It is concluded that the enzymatic locus of action of the compound is dihydrofolate reductase. The selective action of TMP is based on its ability to distinguish structural differences in reductases isolated from various organisms Co-trimoxazole is a combination antibiotic made up of trimethoprim and sulphamethoxazole that is first line treatment for Pneumocystis jirovecii pneumonia (PJP). Hyperkalaemia is a relatively common side effect of the trimethoprim component of co-trimoxazole but it is not well recognised by clinicians. The mechanism of action causing hyperkalaemia due to trimethoprim is similar to the. Co-trimoxazole is used to treat certain bacterial infections, such as pneumonia (a lung infection), bronchitis (infection of the tubes leading to the lungs), and infections of the urinary tract, ears, and intestines. It also is used to treat 'travelers' diarrhea. Subsequently, question is, what is the mechanism of action of cotrimoxazole Mechanism of Action: Sulfamethoxazole inhibits the synthesis of dihydrofolic acid. Trimethoprim inhibits thymidine and DNA synthesis. These two agents act synergistically in inhibiting folic acid synthesis. Pharmacodynamics. Exhibits time-dependent bactericidal activity. Pharmacokinetics ↑Trimethoprim-sulfamethoxazole (co-trimoxazole): Drug information. UpToDate. www.uptodate.com. Accessed April 2, 2019. ↑ Sanford Guide to Antimicrobial Therapy.

Sulfonamides, fluoroquinolones, oxiquinolines, nitrofurans

Sulfamethoxazole and trimethoprim combination is an antibiotic. It works by eliminating the bacteria that cause many kinds of infections. This medicine will not work for colds, flu, or other virus infections. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Tablet Co-trimoxazole is a sulfonamide antibiotic commonly used in immunocompromised individuals, who are already more at risk of ADRs. The most frequent ADRs are morbilliform or urticarial rash; however, serious ADRs can result, most commonly SJS/TEN [16]. Observed cutaneous drug reactions with sulfonamides include

Trimethoprim/sulfamethoxazole - Wikipedi

Trade Names: Sulfamethoxazole with trimethoprim ( Cotrimoxazole or Bactrim ® ) (Septra ®) Mechanism of Action: Sulfonamides competitively inhibit the incorporation of para-aminobenzoic acid (PABA) into dihydropteroic acid, a precursor of folic acid. Trimethoprim is an inhibitor of dihydrofolate reductase and provides a sequential blockade of. Introduction. Co-trimoxazole (a combination of the antibiotics trimethoprim and sulfamethoxazole) is a commonly used treatment in the United States for urinary tract infections 7, and a reported 4000 prescriptions a month are dispensed in Canada.Following concerns in the UK of antibiotic-related Clostridium difficile colitis from other broad-spectrum antibiotics, co-trimoxazole is regaining. The results argue against an antibacterial mechanism of action for sulphasalazine and sulphapyridine in rheumatoid arthritis, unless this occurs at a site inaccessible to sulphamethoxazole. Co-trimoxazole in rheumatoid arthritis: a comparison with sulphapyridine. | Annals of the Rheumatic Disease Mechanism of Action 12.3 . Pharmacokinetics 12.4. Microbiology. 13 NONCLINICAL TOXICOLOGY . 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility. 13.2 Animal Toxicology and/or Pharmacology. 14 CLINICAL STUDIES . 14.1. Complicated Urinary Tract Infection and Pyelonephritis-Efficacy i

The mechanism of action of co-trimoxazole is generic name inhibition bactrim the metabolism of microorganism cells. Special instructions Before using Bactrim, it is imperative to carefully read bactrim generic name instructions and pay attention to such special instructions for its use: Bactrim suspension is not used to treat pregnant women mechanism of action The synergy between trimethoprim and sulfamethoxazole was first described in a series of in vitro and in vivo experiments published in the late 1960s. Trimethoprim and sulfamethoxazole have a greater effect when given together than when given separately; the reason is because they inhibit successive steps in the folate.

Sulfamethoxazole and trimethoprim C24H29N7O6S - PubChe

Co-trimoxazole. Trimethoprim was commonly used in combination with sulfamethoxazole, a sulfonamide antibiotic, which inhibits an earlier step in the folate synthesis pathway (see diagram above). This combination, also known as co-trimoxazole, TMP-sulfa, or TMP-SMX, results in an in vitro synergistic antibacterial effect by inhibiting successive steps in folate synthesis, this claimed benefit. Chlorpheniramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold.These symptoms include rash, watery eyes, itchy eyes/nose/throat/skin, cough, runny nose. In the study by Gompels et al. 41, 4 HIV-positive patients who had reacted to co-trimoxazole after/during desensitization were patch tested, all with negative result. As positive skin tests may represent cellular activation to a very low concentration of the drug in question, desensitization in skin test-positive patients is likely to be more. 11. Co-trimoxazole 960mg once a day on Monday, Wednesday and Friday oral for 28 days Cycle 1 Day 15 1. Dexamethasone 8mg oral or equivalent intravenous dose 2. Ondansetron 8mg oral or intravenous 3. 2Dacarbazine 375mg/m intravenous infusion in 500ml sodium chloride 0.9% over 60 minutes 4. 2Doxorubicin 25mg/m intravenous bolus over 10 minutes 5

Successful Conservative Management of Trimethoprim Induced

Cotrimoxazole : Mechanism Of Action & Rationale - YouTub

Thus, our data for cause of death cannot directly inform about mechanism of action, other than to note a substantial effect of co-trimoxazole prophylaxis on other causes, which could have been because of secondary sepsis.Recurrent pneumonia diagnoses (individually reported as stage 3 events) have been reviewed by the endpoint review committee. The anti-inflammatory action of flurbiprofen suppositories in paediatric urology in comparison with co-trimoxazole. Bono AV, Roggia A. J Int Med Res, 12(2):128-131, 01 Jan 1984 Cited by: 0 articles | PMID: 614460 Introduction. Co-trimoxazole is a combination antibiotic drug containing trimethoprim and sulfamethoxazole, prescribed for multiple indications and is the fourth most commonly prescribed antibiotic in the USA.1 Its use has been associated with an increased risk of sudden death among people taking renin-angiotensin system blockers.2 3 This may be owing to acute kidney injury, a rapid.

Trimethoprim Mechanism Of Action - slidesharedocs

co-trimoxazole (CTZ) (1.44 g/day) to the treatment regimen of patients with RA already receiving treatment with gold, chloroquine, or steroids led to a significant reduction in erythrocyte sedimentation rate and an increase in grip strength.t(t More recently, Ash et al have shown clinical and bio-chemical improvement of disease activity in Mechanism of action of Glibenclamide. Sulfonylureas appear to have several modes of action, apparently mediated by inhibition of ATP-sensitive potassium channels. Initially, secretion of insulin by functioning islet beta cells is increased. Oral antidiabetics of the sulfonylurea type increase the sensitivity of B-cells towards glucose, enabling. Lesson on sulfonamide antibiotics like Trimethoprim-Sulfamethoxazole (Septra), what bacteria sulfonamides target, the mechanism of action of sulfonamides, an.. Co-trimoxazole (Septrin) should not be given to neonates during the first 6 weeks, except for the treatment/prophylaxis of pneumocytosis jiroveci (P. carinii) in infants of four weeks of age or greater. (which is most likely related to the mechanism of action of co-trimoxazole). The active bactrim of 800-160 tab is co-trimoxazole. Their combination in one dosage form allows you to mutually enhance the action of both components. You can Buy Bactrim on our website 800-160 tab. The drug also blocks the final phases of the synthesis of bsctrim and 800-160 tab bases and nucleic acids